Resistance to Bacitracin as Modulated by an Escherichia coli Homologue of the Bacitracin ABC Transporter BcrC Subunit from Bacillus licheniformis
نویسندگان
چکیده
منابع مشابه
A bacitracin-resistant Bacillus subtilis gene encodes a homologue of the membrane-spanning subunit of the Bacillus licheniformis ABC transporter.
Bacitracin is a peptide antibiotic nonribosomally produced by Bacillus licheniformis. The bcrABC genes which confer bacitracin resistance to the bacitracin producer encode ATP binding cassette (ABC) transporter proteins, which are hypothesized to pump out bacitracin from the cells. Bacillus subtilis 168, which has no bacitracin synthesizing operon, has several genes homologous to bcrABC. It was...
متن کاملThe production of bacitracin synthetase by Bacillus licheniformis ATCC 10716.
Bacitracin synthetase is an enzyme complex [ 1,2] composed of three complementary fractions called A, B and C [3] (see fig.1). F’hosphopantetheine which is covalently bound to the fractions [2,3,.5] is probably involved in the biosynthesis of bacitracin. Similar to gramicidin S and tyrocidine [6] its mechanism of synthesis has been described as a thiotemplate mechanism [7]. In the present work ...
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Although the microbial formation of a variety of polypeptides possessing antibiotic activities has been known for some time, the biosynthesis of these compounds has as yet received little attention. Not only is the mechatnism of formation of these biologically active compounds of interest in itself, but the biosyntheses of these polypeptides are potential systems for investigating the general p...
متن کاملEnhanced Production of Bacitracin by a Mutant Strain Bacillus Licheniformis Uv-mn-hn-8 (enhanced Bacitracin Production by Mutagenesis)
The present study is focused on the improvement of Bacillus licheniformis through random mutagenesis to obtain mutant having enhanced production of bacitracin. Many isolates of Bacillus licheniformis were isolated and the isolate GP-40 produced maximum bacitracin production (16±0.72 IU/mL). Treatment of Bacillus licheniformis GP-40 with ultraviolet (UV) radiations increased bacitracin productio...
متن کاملAn ABC transporter of Streptococcus pneumoniae involved in susceptibility to vancoresmycin and bacitracin.
Vancoresmycin is a novel tetramic acid antibiotic, probably interfering with functions of the cytoplasmic membrane. To investigate its mode of action, mutants of Streptococcus pneumoniae exhibiting reduced susceptibility to vancoresmycin were isolated at a low frequency. Four of them were further examined and showed similar pleiotropic phenotypes, including reduced growth rate, early autolysis,...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1999
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.181.19.6176-6178.1999